Gene-edited chickens to help preserve rare breeds

Hens that do not produce their own chicks have been developed for use as surrogates to lay eggs from rare breeds.  The advance – using gene-editing techniques – could help to boost breeding of endangered birds, as well as improving production of commercial hens, researchers say.

DNA deletion

A team led by the University of Edinburgh’s Roslin Institute used a genetic tool called TALEN to delete a section of chicken DNA.

They targeted part of a gene called DDX4, which is crucial for bird fertility.

Infertile

Hens with the genetic modification were unable to produce eggs but were otherwise healthy, the team found.  DDX4 plays an essential role in the generation of specialised cells – called primordial germ cells – which give rise to eggs.

Surrogate hens

Researchers say that primordial germ cells from other bird breeds could be implanted into eggs carrying the gene edited birds.  The hens would then grow up to produce eggs containing all of the genetic information from the other breeds.

These chickens are a first step in saving and protecting rare poultry breeds from loss in order to preserve future biodiversity of our poultry from both economic and climate stresses.

Dr Mike McGrew, The Roslin Institute

First in Europe

The surrogate chickens are the first gene-edited birds to be produced in Europe. Scientists from the US biotechnology company Recombinetics also worked on the project.

The study is published in the journal Development and was funded by strategic investment from the Biotechnology and Biological Sciences Research Council.

Related links

Journal article

Source: https://www.ed.ac.uk/news/2017/gene-edited-chickens-to-help-preserve-rare-breeds

Leave a Reply

Your email address will not be published. Required fields are marked *